Awọn Abuda Ipilẹ

ọja orukọ	TAK-438 lulú
CAS Number	1260141-27-2
molikula agbekalẹ	C21H20FN3O6S
Ilana iwuwo	461.46
Awọn Synonyms	Vonoprazan Fumarate; TAK-438 lulú; 1260141-27-2; Vonoprazan fumurate; TAK438.
irisi	Funfun si pipa-funfun lulú
Ifipamọ ati mimu	Gbẹ, okunkun ati ni 0 - 4 C fun igba kukuru (awọn ọjọ si awọn ọsẹ) tabi -20 C fun igba pipẹ (awọn oṣu si ọdun).

 

TAK-438 lulú Apejuwe

TAK438, ti a tun mọ ni Vonoprazan Fumarate, jẹ oogun tuntun fun atọju awọn aisan ti o ni acid pẹlu ilana aramada ti iṣe ti a pe ni awọn oluṣeto acid ifigagbaga ti potasiomu (P-CABs) eyiti o ni idije dena didapọ awọn ions potasiomu si H +, K + -ATPase ( tun mọ bi fifa proton) ni igbesẹ ikẹhin ti yomijade ti acid inu inu awọn sẹẹli parietal inu, awọn idari yomijade ti inu. O pese ipa idena yomijade ti acid lagbara ati atilẹyin.

Ninu awọn keekeke ti inu gbin, itọju lulú TAK-438 yorisi idena iṣelọpọ acid to gun ati okun sii. Ipa idiwọ ti TAK-438 lulú lori yomijade acid dabi ẹni pe o ni nkan ṣe pẹlu physiology cell parietal cell.

 

TAK-438 lulú Iṣaṣe ti Ise

Lulú TAK-438 (Vonoprazan fumarate) jẹ itọsẹ pyrole kan ati oludena acid ifigagbaga ti potasiomu (P-CAB) eyiti o ni idije idije awọn aaye isopọ ti potasiomu ti H (+), K (+) - ATPase, enzymu bọtini kan ninu ilana ti yomijade ti inu acid. Apopọ le ṣajọ ni awọn agbegbe acid ati pe o yẹ ki o pese akoko gigun ti idinamọ nitori pKa ipilẹ ti 9.06.

Ninu awọn keekeke ti inu gbin, itọju lulú TAK-438 yorisi idena iṣelọpọ acid to gun ati okun sii. Ipa idiwọ ti TAK-438 lulú lori yomijade acid dabi ẹni pe o ni nkan ṣe pẹlu physiology cell parietal cell.

 

Ohun elo lulú TAK-438

Lulú TAK-438 (Vonoprazan fumarate tabi Vonoprazan) jẹ oogun tuntun fun titọju awọn aisan ti o ni acid pẹlu ilana aramada ti iṣe ti a pe ni awọn oludena acid ifigagbaga ti potasiomu (P-CABs) eyiti o ni idije dena didapọ awọn ions potasiomu si H +, K + - ATPase (ti a tun mọ ni fifa proton) ni igbesẹ ikẹhin ti yomijade acid acid ninu awọn sẹẹli parietal inu. A fọwọsi oogun naa ni ilu Japan fun itọju awọn arun ti o ni ibatan acid, pẹlu ọgbẹ inu, ọgbẹ duodenal, reflux esophagitis ati Adjunct si iparun Helicobacter pylori ninu ọran Helicobacter pylori gastritis.

 

TAK-438 lulú Awọn ipa Ipa & Ikilọ

Awọn ipa ẹgbẹ ti o wọpọ pẹlu:

▪ gbuuru,

▪ inu ati eebi,

▪ àìrígbẹyà,

Pain irora inu,

Rash awọ ara,

▪ ibinujẹ.

 

Iwọnyi kii ṣe gbogbo awọn ipa ẹgbẹ ti o ṣeeṣe ti TAK438. Fun alaye diẹ sii, beere lọwọ dokita rẹ tabi oniwosan oogun. Pe dokita rẹ fun imọran iṣoogun nipa awọn ipa ẹgbẹ. O le ṣe ijabọ awọn ipa ẹgbẹ si FDA ni 1-800-FDA-1088.

 

Reference

[1] Arikawa Y, Nishida H, Kurasawa O, Hasuoka A, Hirase K, Inatomi N, Hori Y, Matsukawa J, Imanishi A, Kondo M, Tarui N, Hamada T, Takagi T, Takeuchi T, Kajino M. Awari ti aratuntun itọsẹ pyrrole 1- [5- (2-fluorophenyl) -1- (pyridin-3-ylsulfonyl) -1H-pyrrol-3-yl] -N-methylmethanamin e fumarate (TAK-438 powder) gege bi ifigagbaga ti potasiomu ohun amorindun acid (P-CAB). J Med Chem. 2012 Oṣu Kẹwa 10; 55 (9): 4446-56. ṣe: 10.1021 / jm300318t. Epub 2012 Oṣu Kẹrin 30. PubMed PMID: 22512618.

[2] Kondo M, Kawamoto M, Hasuoka A, Kajino M, Inatomi N, Tarui N. Ṣiṣayẹwo ṣiṣiparọ giga ti awọn idiwọ acid ifigagbaga ti potasiomu. J Iboju Biomol. 2012 Kínní; 17 (2): 177-82. ṣe: 10.1177 / 1087057111421004. Epub 2011 Oṣu Kẹsan 22. PubMed PMID: 21940711.

[3] Shin JM, Inatomi N, Munson K, Strugatsky D, Tokhtaeva E, Vagin O, Sachs G. Ihuwasi ti aratuntun ifigagbaga potasiomu-ifigagbaga acid ti inu H, K-ATPase, 1- [5- (2- fluorophenyl) -1- (pyridin-3-ylsulfonyl) -1H-pyrrol-3-yl] -N-methylmethanamin e monofumarate (TAK-438 lulú). J Pharmacol Exp Ther. Oṣu kọkanla 2011; 339 (2): 412-20. ṣe: 10.1124 / jpet.111.185314. Epub 2011 Aug 9. PubMed PMID: 21828261; PubMed Central PMCID: PMC3199995.

[4] Hori Y, Matsukawa J, Takeuchi T, Nishida H, Kajino M, Inatomi N. Iwadi kan ti o ṣe afiwe ipa antisecretory ti lulú TAK-438, iwe-akọọlẹ acid-ifigagbaga acid ifigagbaga, pẹlu lansoprazole ninu awọn ẹranko. J Pharmacol Exp Ther. Oṣu Kẹwa 2011; 337 (3): 797-804. ṣe: 10.1124 / jpet.111.179556. Epub 2011 Mar 16. PubMed PMID: 21411494.

[5] Matsukawa J, Hori Y, Nishida H, Kajino M, Inatomi N. Iwadi afiwera lori awọn ipo iṣe ti lulú TAK-438, aramada amuludun ifigagbaga potasiomu-ifigagbaga, ati lansoprazole ni akọkọ awọn ehoro ti o ni ibatan ehoro. Biochem Pharmacol. 2011 Oṣu Karun 1; 81 (9): 1145-51. ṣe: 10.1016 / j.bcp.2011.02.009. Epub 2011 Mar 1. PubMed PMID: 21371447.

[6] Hori Y, Imanishi A, Matsukawa J, Tsukimi Y, Nishida H, Arikawa Y, Hirase K, Kajino M, Inatomi N. 1- [5- (2-Fluorophenyl) -1- (pyridin-3-ylsulfonyl) -1H-pyrrol-3-yl] -N-methylmethanamin e monofumarate (TAK-438 lulú), iwe-akọọlẹ kan ati amuna acid ifigagbaga ti ifigagbaga ti potasiomu fun itọju awọn aisan ti o ni ibatan acid. J Pharmacol Exp Ther. Oṣu Kẹwa 2010; 335 (1): 231-8. ṣe: 10.1124 / jpet.110.170274. Epub 2010 Jul 12. PubMed PMID: 20624992.

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