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MMAD (Demethyldolastatin 10)

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SKU: 203849-91-6. Ẹka:

AASraw jẹ pẹlu kolaginni ati gbóògì agbara lati giramu to ibi ibere ti MMAD (Demethyldolastatin 10) (CAS 203849-91-6), labẹ CGMP ilana ati trackable didara iṣakoso eto.

afikun ohun ti, MMAD ti wa ni royin lati lo ninu iṣelọpọ awọn conjugates oògùn (anti-drug antibody drug conjugates). Ninu awọn NDC, MMAD ti wa ni idapo pelu antibody 5T4 tabi antibody Her2. O han pe Awọn NDC nfi ipa ti o dara julọ ati awọn pharmacokinetics han.

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MMAD (Demethyldolastatin 10) fidio


MMAD (Demethyldolastatin 10) awọn lẹta ipilẹ

Name: MMAD (Demethyldolastatin 10)
CAS: 203849-91-6
Molikula agbekalẹ: C41H66N6O6S
Iwon-ara ti iṣuu: 771.06
Orisun Isanmi: N / A
Ibi ipamọ Temp: Awọn ọdun Powder -20 ° C 3
4 ° C 2 ọdun
Ninu osu -80 ° C 6 osu
-20 ° C 1 oṣu
awọ: Funfun si pipa-funfun (ti o lagbara)


MMAD (10 Demethyldolastatin) (203849-91-6) lilo ni awọn oniroyin sitẹriọdu

awọn orukọ

Synonyms: Demethyldolastatin 10 (203849-91-6); Monomethylauristatin D; Monomethyl Dolastatin 10
Chemical Name: (S)-N-((3R,4S,5S)-3-methoxy-1-((S)-2-((1R,2R)-1-methoxy-2-methyl-3-oxo-3-(((S)-2-phenyl-1-(thiazol-2-yl)ethyl)amino)propyl)pyrrolidin-1-yl)-5-methyl-1-oxoheptan-4-yl)-N,3-dimethyl-2-((S)-3-methyl-2-(methylamino)butanamido)butanamide

Ikilo lori MMAD (Demethyldolastatin 10)

Ọja ko ti ni kikun ti ni ilọsiwaju fun awọn ohun elo egbogi. Fun lilo iwadi nikan

Fun gba kan ti o ga solubility, jọwọ gbona tube ni 37 ℃ ati ki o gbọn o ni ultrasonic wẹ fun a while.Stock ojutu le ti wa ni fipamọ ni isalẹ -20 ℃ fun ọpọlọpọ awọn osu.

Awọn itọnisọna siwaju sii

Ni fitiro: MMAD (Demethyldolastatin 10) (203849-91-6) ti wa ni pelu nipasẹ kan idurosinsin oxime-ligation ilana lati ikore orisirisi sunmọ-homogenous agboguntaisan-oògùn conjugates (ADCs) pẹlu kan oògùn-to-agboguntaisan ipin ti ~ 2.0. Awọn conjugates ti o ṣe apẹẹrẹ nfihan awọn ohun ti o dara fun pharmacokinetic, iṣelọpọ cytotoxic ti o lagbara ninu awọn nkan ẹjẹ HER2 +. Nigbati a ba ṣe akawe pẹlu ADCs ti a pese nipasẹ cysteine ​​alkylation lẹhin atẹgun intercain disulfide, awọn adarọ-ara ADCs ti amino-acid-specifics-ojula-han ni a fihan pe o ti pọ si cytotoxicity in vitro

Ni Vivi: Awọn ọlọjẹ egboogi egboogi-egbogi (ADCs) ṣe afihan ifarahan ipilẹ gbogbo ni awọn opo. Wọn tun ni profaili toxicology dara si ni awọn eku.


Bawo ni lati ra MMAD; ra Demethyldolastatin 10 lati AASraw

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