MMAD (Demethyldolastatin 10)

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AASraw jẹ pẹlu kolaginni ati gbóògì agbara lati giramu to ibi ibere ti MMAD (Demethyldolastatin 10) (CAS 203849-91-6), labẹ CGMP ilana ati trackable didara iṣakoso eto.

afikun ohun ti, MMAD ti wa ni royin lati lo ninu iṣelọpọ awọn conjugates oògùn (anti-drug antibody drug conjugates). Ninu awọn NDC, MMAD ti wa ni idapo pelu antibody 5T4 tabi antibody Her2. O han pe Awọn NDC nfi ipa ti o dara julọ ati awọn pharmacokinetics han.

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MMAD (Demethyldolastatin 10) fidio


I.MMAD (Demethyldolastatin 10) awọn ẹya ipilẹ:

Name: MMAD (Demethyldolastatin 10)
CAS: 203849-91-6
Molikula agbekalẹ: C41H66N6O6S
Iwon-ara ti iṣuu: 771.06
Orisun Isanmi: N / A
Ibi ipamọ Temp: Awọn ọdun Powder -20 ° C 3
4 ° C 2 ọdun
Ninu osu -80 ° C 6 osu
-20 ° C 1 oṣu
awọ: Funfun si pipa-funfun (ti o lagbara)


II. MMAD (10 Demethyldolastatin) (203849-91-6) lilo ni awọn oniroyin sitẹriọdu

1.Names:

Synonyms: Demethyldolastatin 10 (203849-91-6); Monomethylauristatin D; Monomethyl Dolastatin 10
Chemical Name: (S)-N-((3R,4S,5S)-3-methoxy-1-((S)-2-((1R,2R)-1-methoxy-2-methyl-3-oxo-3-(((S)-2-phenyl-1-(thiazol-2-yl)ethyl)amino)propyl)pyrrolidin-1-yl)-5-methyl-1-oxoheptan-4-yl)-N,3-dimethyl-2-((S)-3-methyl-2-(methylamino)butanamido)butanamide

2.MMAD (Demethyldolastatin 10) Lilo:

3.Warning lori MMAD (Demethyldolastatin 10)

Ọja ko ti ni kikun ti ni ilọsiwaju fun awọn ohun elo egbogi. Fun lilo iwadi nikan

Fun gba kan ti o ga solubility, jọwọ gbona tube ni 37 ℃ ati ki o gbọn o ni ultrasonic wẹ fun a while.Stock ojutu le ti wa ni fipamọ ni isalẹ -20 ℃ fun ọpọlọpọ awọn osu.

4.Firther instructions:

Ni fitiro: MMAD (Demethyldolastatin 10) (203849-91-6) ti wa ni pelu nipasẹ kan idurosinsin oxime-ligation ilana lati ikore orisirisi sunmọ-homogenous agboguntaisan-oògùn conjugates (ADCs) pẹlu kan oògùn-to-agboguntaisan ipin ti ~ 2.0. Awọn conjugates ti o ṣe apẹẹrẹ nfihan awọn ohun ti o dara fun pharmacokinetic, iṣelọpọ cytotoxic ti o lagbara ninu awọn nkan ẹjẹ HER2 +. Nigbati a ba ṣe akawe pẹlu ADCs ti a pese nipasẹ cysteine ​​alkylation lẹhin atẹgun intercain disulfide, awọn adarọ-ara ADCs ti amino-acid-specifics-ojula-han ni a fihan pe o ti pọ si cytotoxicity in vitro

Ni Vivi: Awọn ọlọjẹ egboogi egboogi-egbogi (ADCs) ṣe afihan ifarahan ipilẹ gbogbo ni awọn opo. Wọn tun ni profaili toxicology dara si ni awọn eku.


III. MMAD (10 Demethyldolastatin) (203849-91-6) HCML

A jẹ Agbegbe apanirun imupọ, Eporo ti a koju fun tita, Epo Agbara Agbejade (170729-80-3) hplc≥98% | Aṣraw R & D Reagents


IV. Bawo ni lati ra MMAD; ra Demethyldolastatin 10 lati AASraw?

1.Lọ kan si wa nipasẹ imeeli wa eto iwadi, tabi skype oju-ọrunaṣoju iṣẹ onibara (CSR).
2.Lati fun wa ni idiyele ati adirẹsi rẹ.
3.OUR CSR yoo fun ọ ni sisọ, ọrọ igbanwo, nọmba ipasẹ, awọn ọna ifijiṣẹ ati ipo ti a ti pinnu opin (ETA).
4.Payment ti ṣe ati awọn ọja naa yoo wa ni awọn wakati 12 (Fun aṣẹ laarin 10kg).
5.Goods gba ati fun awọn esi.


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Alaye siwaju sii nipa awọn ọja ti o yẹ,kaabo lati tẹ nibi.


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