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Trilostane lulú (13647-35-3)

Rating: SKU: 13647-35-3. Ẹka:

AASraw wa pẹlu iṣelọpọ ati agbara iṣelọpọ lati gram si aṣẹ pupọ ti Trilostane Powder (13647-35-3), labẹ ilana CGMP ati eto iṣakoso didara didara.

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Trilostane lulú (13647-35-3) fidio


Trilostane lulú (13647-35-3) Specification:

Ẹya Kẹmika: ọja orukọ: Trilostane
CAS No.: 13647-35-3
molikula agbekalẹ: C20H27NO3
molikula iwuwo: 329.43
Standard: Ni ile
Ibi: Gbẹ, dudu ati 0 - 4 C fun igba diẹ (ọjọ si awọn ọsẹ) tabi -20 C fun igba pipẹ (osu si ọdun).
Awọn iwe aṣẹ (COA & HPLC ati bẹbẹ lọ): wa

Trilostane lulú (13647-35-3) Dorukọ:

Trilostane lulú jẹ inhibitor ti 3β-hydroxysteroid dehydrogenase ti a lo ninu itọju itọju ailera ti Cushing ati hyperaldosteronism akọkọ. Iwọnyi jẹ awọn rudurudu mejeeji nibiti ọpọlọpọ awọn homonu corticosteroid ṣe agbejade ninu ara. Awọn corticosteroids jẹ pataki fun ara lati ṣe lilo awọn carbohydrates, awọn ọra ati awọn ọlọjẹ ati fun esi deede si aapọn. Wọn tun jẹ pataki fun ilana iyọ ati iwontunwonsi omi ninu ara. Trilostane lulú ṣe iranlọwọ idiwọ iṣelọpọ ti corticosteroids, ṣiṣakoso awọn ami ti o ni nkan ṣe pẹlu awọn rudurudu wọnyi.

Trilostane lulú tun le wulo ni itọju ti akàn igbaya ti o ti tun pada ninu awọn obinrin ti o ti kọja menopause.

O ti fọwọsi laipe ni ọdun 2008 fun itọju ti arun Cushing (hyperandrenocorticism) ninu awọn aja. O tun jẹ oogun akọkọ ti a fọwọsi lati ṣe itọju mejeeji pituitary- ati Cushing-ti o gbẹkẹle adari-eegun ninu awọn aja. Oogun oogun yii n ṣiṣẹ nipa didaduro iṣelọpọ cortisol ni awọn keekeke ti adrenal.

Reference:

  • 1: Midence JN, Drobatz KJ, Hess RS. Awọn iṣaro Cortisol ni Awọn aja Awọn Itunra Daradara pẹlu Hyperadrenocorticism Mu pẹlu Trilostane. J Vet Intern Med. Oṣu kọkanla 2015; 29 (6): 1529-33. doi: 10.1111 / jvim.13615. Epub 2015 Oṣu Kẹsan 16. PMMe PMID: 26374943.
  • 2: Fracassi F, Corradini S, Floriano D, Boari A, Aste G, Pietra M, Bergamini PF, Dondi F. Awọn okunfa prognostic fun iwalaaye ninu awọn aja pẹlu hypercortisolism hyucortisolism ti a tọju pẹlu trilostane. Vet Rec. 2015 Oṣu kini 10; 176 (2): 49. doi: 10.1136 / vr.102546. Epub 2014 Aug 28. PubMed PMID: 25170036.
  • 3: Bonadio CM, Feldman EC, Cohen TA, Kass PH. Ifiwera ti awọn abajade iwuri homonu adrenocorticotropic bẹrẹ ni 2 lẹgbẹẹ awọn wakati mẹrin lẹhin iṣakoso trilostane ninu awọn aja pẹlu ti ara ẹni ti o waye hyperadrenocorticism nipa ti ara. J Vet Intern Med. Ọdun 4 Keje-Aug; 2014 (28): 4-1239. doi: 43 / jvim.10.1111. Epub 12357 May 2014. PubMed PMID: 26.

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